منابع مشابه
Biomarkers for immune intervention trials in type 1 diabetes.
After many efforts to improve and standardize assays for detecting immune biomarkers in type 1 diabetes (T1D), methods to identify and monitor such correlates of insulitis are coming of age. The ultimate goal is to use these correlates to predict disease progression before onset and regression following therapeutic intervention, which would allow performing smaller and shorter pilot clinical tr...
متن کاملImmune Intervention in Type I Diabetes Mellitus
In many countries Type 1 diabetes [T1D] is the most common life-threatening disease in chil‐ dren, and nobody can be cured. For long time the incidence has increased all over the world [1]. The disease causes serious morbidity and increased mortality [2,3] in spite of an intensive treatment with multiple daily injections of insulin, adapted to regular meals with suitable content based on self-m...
متن کاملFuture intervention trials in type 1 diabetes.
The recently completed trials using insulin (U.S.) and nicotinamide (Europe) were not effective in preventing type 1 diabetes (1,2), but they leave an important legacy of goodwill among their collaborators and expertise in the conduct of such trials and a network through which more may be carried out. A commentary on the trials has recently been published (3), and its authors urge “a different ...
متن کاملAltered Immune Regulation in Type 1 Diabetes
Research in genetics and immunology was going on separate strands for a long time. Type 1 diabetes mellitus might not be characterized with a single pathogenetic factor. It develops when a susceptible individual is exposed to potential triggers in a given sequence and timeframe that eventually disarranges the fine-tuned immune mechanisms that keep autoimmunity under control in health. Genomewid...
متن کاملDiabetes Updates on Immune Therapies in Type 1 Diabetes
M ultiple clinical trials investigating the efficacy and safety of immunotherapeutic interventions in new onset type 1 diabetes (T1D) have failed to yield long term clinical benefit. Lack of efficacy has frequently been attributed to an incomplete understanding of the pathways involved in T1D and the use of single immunotherapeutic agents. Recent mechanistic studies have improved our knowledge ...
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ژورنال
عنوان ژورنال: Diabetes Technology & Therapeutics
سال: 2020
ISSN: 1520-9156,1557-8593
DOI: 10.1089/dia.2020.2511